| YEAR | PLAYER | TEAM | OPPONENT | YARDS | 2003 | JAMAL LEWIS | BALTIMORE RAVENS | CLEVELAND BROWNS | 295 |
| 2000 | COREY DILLION | CINCINNATI BENGALS | DENVER BRONCOS | 278 |
| 1977 | WALTER PAYTON | CHICAGO BEARS | MINNESOTA VIKINGS | 275 |
| 1976 | O.J. SIMPSON | BUFFALO BILLS | DETROIT LIONS | 273 |
| 2001 | SHAUN ALEXANDER | SEATTLE SEAHAWKS | OAKLAND RAIDERS | 266 |